Thermodynamics of sequence-specific protein-DNA interactions
Identifieur interne : 002608 ( Main/Exploration ); précédent : 002607; suivant : 002609Thermodynamics of sequence-specific protein-DNA interactions
Auteurs : Torleif H Rd [Suède] ; Thomas Lundb Ck [Suède]Source :
- Biophysical Chemistry [ 0301-4622 ] ; 1996.
Abstract
The molecular recognition processes in sequence-specific protein-DNA interactions are complex. The only feature common to all sequence-specific protein-DNA structures is a large interaction interface, which displays a high degree of complementarity in terms of shape, polarity and electrostatics. Many molecular mechanisms act in concert to form the specific interface. These include conformational changes in DNA and protein, dehydration of surfaces, reorganization of ion atmospheres, and changes in dynamics. Here we review the current understanding of how different mechanisms contribute to the thermodynamics of the binding equilibrium and the stabilizing effect of the different types of noncovalent interactions found in protein-DNA complexes. The relation to the thermodynamics of small molecule-DNA binding and protein folding is also briefly discussed.
Url:
DOI: 10.1016/S0301-4622(96)02197-7
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en">The molecular recognition processes in sequence-specific protein-DNA interactions are complex. The only feature common to all sequence-specific protein-DNA structures is a large interaction interface, which displays a high degree of complementarity in terms of shape, polarity and electrostatics. Many molecular mechanisms act in concert to form the specific interface. These include conformational changes in DNA and protein, dehydration of surfaces, reorganization of ion atmospheres, and changes in dynamics. Here we review the current understanding of how different mechanisms contribute to the thermodynamics of the binding equilibrium and the stabilizing effect of the different types of noncovalent interactions found in protein-DNA complexes. The relation to the thermodynamics of small molecule-DNA binding and protein folding is also briefly discussed.</div>
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